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:::::::All colonies and regular colony [[Upgrades|'''upgrades''']] are used up when attacking a [[Planets|'''planet''']] or entering a [[Black Hole]]. Gene strand upgrades to colony production are only lost when entering a Black Hole, but BPC and BPS bonuses from the '''[[Dark Matter Institute]]''' and '''Premium purchases''' are permanent.
:::::::The effective production of colonies is also influenced by the equipped [[Evolved Bacteria|'''
evolved bacteria''']], which can boost the total BPS, [[BPS#Idle BPS|idle BPS]], or reduce colony price.