All colonies and regular colony [[Upgrades|'''upgrades ''']] are used up when attacking a [[Planets|'''planet''']] or entering a '''[[Black Hole]]'''.

Colony Gene strand upgrades to colony production are only lost when entering a Black Hole, but BPC and BPS bonuses from the '''[[Dark Matter Institute]]''' and '''Premium purchases''' are permanent. The effective production of colonies is also influenced by the equipped [[Evolved Bacteria|'''evolved bacteria''']], which can be increased from Coloboost the total BPS, [[BPS#Idle BPS|idle BPS]], or reduce colony price.